Macchia d'Isernia is a comune in the Province of Isernia in the Italian region Molise, located about 40 kilometres west of Campobasso and about 7 kilometres southwest of Isernia. Macchia d'Isernia borders the following municipalities: Colli a Volturno, Fornelli, Isernia, Monteroduni, Sant'Agapito.
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