The epigenetic clock, biological age, and chronic diseases
The epigenetic clock, biological age, and chronic diseases
Air date: Wednesday, June 15, 2016, 3:00:00 PM
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:03:40
Description: NIH Director’s Wednesday Afternoon Lecture Series
It has been a long standing goal to develop molecular biomarkers of biological age. Recent studies demonstrate that powerful epigenetic biomarkers of aging can be defined based on DNA methylation levels. For example, the epigenetic clock (PMID: 24138928) is a multivariate age estimation method that applies to sorted cell types (CD4T cells or neurons), complex tissues, and organs and even prenatal brain samples. The epigenetic clock is an attractive biomarker of aging because a) it applies to most human and chimpanzee tissues, b) its accurate measurement of chronological age is unprecedented, c) it is predictive of all-cause mortality even after adjusting for a variety of known risk factors, d) it correlates with measures of cognitive and physical fitness in the elderly, and e) it has been found useful for detecting accelerated aging effects due to obesity, Down syndrome, and HIV infection. Recent genomewide association studies shed light on the underlying biological mechanisms.
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Author: Steve Horvath, Sc.D., Ph.D., University of California, Los Angeles
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How to Grow Organic Kiwi
Learn how to plant and grow a hardy kiwi. Kiwis are a relatively disease free vine that is hardy to zone 4. These little kiwis are fuzzless, sweeter, and higher in vitamin C than fuzzy kiwis.
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How To Do A Hip Swing
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How to Care for Italian Cypress Trees
How to Care for Italian Cypress Trees. Elegantly slender conifers that can reach 60 feet in height with only a 3- to 10-foot width, Italian cypresses (Cupressus sempervirens) look best near tall buildings, as their proportions are too towering for single-story structures. Native to the Mediterranean, the trees produce 1/2- to 1-inch brown cones and...
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The Great Gildersleeve: Jolly Boys Invaded / Marjorie's Teacher / The Baseball Field
Premiering on August 31, 1941, The Great Gildersleeve moved the title character from the McGees' Wistful Vista to Summerfield, where Gildersleeve now oversaw his late brother-in-law's estate and took on the rearing of his orphaned niece and nephew, Marjorie (originally played by Lurene Tuttle and followed by Louise Erickson and Mary Lee Robb) and Leroy Forester (Walter Tetley). The household also included a cook named Birdie. Curiously, while Gildersleeve had occasionally spoken of his (never-present) wife in some Fibber episodes, in his own series the character was a confirmed bachelor.
In a striking forerunner to such later television hits as Bachelor Father and Family Affair, both of which are centered on well-to-do uncles taking in their deceased siblings' children, Gildersleeve was a bachelor raising two children while, at first, administering a girdle manufacturing company (If you want a better corset, of course, it's a Gildersleeve) and then for the bulk of the show's run, serving as Summerfield's water commissioner, between time with the ladies and nights with the boys. The Great Gildersleeve may have been the first broadcast show to be centered on a single parent balancing child-rearing, work, and a social life, done with taste and genuine wit, often at the expense of Gildersleeve's now slightly understated pomposity.
Many of the original episodes were co-written by John Whedon, father of Tom Whedon (who wrote The Golden Girls), and grandfather of Deadwood scripter Zack Whedon and Joss Whedon (creator of Buffy the Vampire Slayer, Firefly and Dr. Horrible's Sing-Along Blog).
The key to the show was Peary, whose booming voice and facility with moans, groans, laughs, shudders and inflection was as close to body language and facial suggestion as a voice could get. Peary was so effective, and Gildersleeve became so familiar a character, that he was referenced and satirized periodically in other comedies and in a few cartoons.
The Great Gildersleeve: A Job Contact / The New Water Commissioner / Election Day Bet
The Great Gildersleeve (1941--1957), initially written by Leonard Lewis Levinson, was one of broadcast history's earliest spin-off programs. Built around Throckmorton Philharmonic Gildersleeve, a character who had been a staple on the classic radio situation comedy Fibber McGee and Molly, first introduced on Oct. 3, 1939, ep. #216. The Great Gildersleeve enjoyed its greatest success in the 1940s. Actor Harold Peary played the character during its transition from the parent show into the spin-off and later in a quartet of feature films released at the height of the show's popularity.
On Fibber McGee and Molly, Peary's Gildersleeve was a pompous windbag who became a consistent McGee nemesis. You're a haa-aa-aa-aard man, McGee! became a Gildersleeve catchphrase. The character was given several conflicting first names on Fibber McGee and Molly, and on one episode his middle name was revealed as Philharmonic. Gildy admits as much at the end of Gildersleeve's Diary on the Fibber McGee and Molly series (Oct. 22, 1940).
He soon became so popular that Kraft Foods—looking primarily to promote its Parkay margarine spread — sponsored a new series with Peary's Gildersleeve as the central, slightly softened and slightly befuddled focus of a lively new family.
Premiering on August 31, 1941, The Great Gildersleeve moved the title character from the McGees' Wistful Vista to Summerfield, where Gildersleeve now oversaw his late brother-in-law's estate and took on the rearing of his orphaned niece and nephew, Marjorie (originally played by Lurene Tuttle and followed by Louise Erickson and Mary Lee Robb) and Leroy Forester (Walter Tetley). The household also included a cook named Birdie. Curiously, while Gildersleeve had occasionally spoken of his (never-present) wife in some Fibber episodes, in his own series the character was a confirmed bachelor.
In a striking forerunner to such later television hits as Bachelor Father and Family Affair, both of which are centered on well-to-do uncles taking in their deceased siblings' children, Gildersleeve was a bachelor raising two children while, at first, administering a girdle manufacturing company (If you want a better corset, of course, it's a Gildersleeve) and then for the bulk of the show's run, serving as Summerfield's water commissioner, between time with the ladies and nights with the boys. The Great Gildersleeve may have been the first broadcast show to be centered on a single parent balancing child-rearing, work, and a social life, done with taste and genuine wit, often at the expense of Gildersleeve's now slightly understated pomposity.
Many of the original episodes were co-written by John Whedon, father of Tom Whedon (who wrote The Golden Girls), and grandfather of Deadwood scripter Zack Whedon and Joss Whedon (creator of Buffy the Vampire Slayer, Firefly and Dr. Horrible's Sing-Along Blog).
The key to the show was Peary, whose booming voice and facility with moans, groans, laughs, shudders and inflection was as close to body language and facial suggestion as a voice could get. Peary was so effective, and Gildersleeve became so familiar a character, that he was referenced and satirized periodically in other comedies and in a few cartoons.
The Great Gildersleeve: Leroy Smokes a Cigar / Canary Won't Sing / Cousin Octavia Visits
The Great Gildersleeve (1941--1957), initially written by Leonard Lewis Levinson, was one of broadcast history's earliest spin-off programs. Built around Throckmorton Philharmonic Gildersleeve, a character who had been a staple on the classic radio situation comedy Fibber McGee and Molly, first introduced on Oct. 3, 1939, ep. #216. The Great Gildersleeve enjoyed its greatest success in the 1940s. Actor Harold Peary played the character during its transition from the parent show into the spin-off and later in a quartet of feature films released at the height of the show's popularity.
On Fibber McGee and Molly, Peary's Gildersleeve was a pompous windbag who became a consistent McGee nemesis. You're a haa-aa-aa-aard man, McGee! became a Gildersleeve catchphrase. The character was given several conflicting first names on Fibber McGee and Molly, and on one episode his middle name was revealed as Philharmonic. Gildy admits as much at the end of Gildersleeve's Diary on the Fibber McGee and Molly series (Oct. 22, 1940).
Premiering on August 31, 1941, The Great Gildersleeve moved the title character from the McGees' Wistful Vista to Summerfield, where Gildersleeve now oversaw his late brother-in-law's estate and took on the rearing of his orphaned niece and nephew, Marjorie (originally played by Lurene Tuttle and followed by Louise Erickson and Mary Lee Robb) and Leroy Forester (Walter Tetley). The household also included a cook named Birdie. Curiously, while Gildersleeve had occasionally spoken of his (never-present) wife in some Fibber episodes, in his own series the character was a confirmed bachelor.
In a striking forerunner to such later television hits as Bachelor Father and Family Affair, both of which are centered on well-to-do uncles taking in their deceased siblings' children, Gildersleeve was a bachelor raising two children while, at first, administering a girdle manufacturing company (If you want a better corset, of course, it's a Gildersleeve) and then for the bulk of the show's run, serving as Summerfield's water commissioner, between time with the ladies and nights with the boys. The Great Gildersleeve may have been the first broadcast show to be centered on a single parent balancing child-rearing, work, and a social life, done with taste and genuine wit, often at the expense of Gildersleeve's now slightly understated pomposity.
Many of the original episodes were co-written by John Whedon, father of Tom Whedon (who wrote The Golden Girls), and grandfather of Deadwood scripter Zack Whedon and Joss Whedon (creator of Buffy the Vampire Slayer, Firefly and Dr. Horrible's Sing-Along Blog).
The key to the show was Peary, whose booming voice and facility with moans, groans, laughs, shudders and inflection was as close to body language and facial suggestion as a voice could get. Peary was so effective, and Gildersleeve became so familiar a character, that he was referenced and satirized periodically in other comedies and in a few cartoons.
Kathleen Stockwell on Nicaragua and El Salvador
Nicaragua, officially the Republic of Nicaragua (Spanish: República de Nicaragua, is the largest country in the Central American isthmus, bordered by Honduras to the north and Costa Rica to the south. The country is situated between 11 and 14 degrees north of the Equator in the Northern Hemisphere, which places it entirely within the tropics. The Pacific Ocean lies to the west, and the Caribbean Sea to the east. The country's physical geography divides it into three major zones: Pacific lowlands; wet, cooler central highlands; and the Caribbean lowlands. On the Pacific side of the country are the two largest fresh water lakes in Central America—Lake Managua and Lake Nicaragua. Surrounding these lakes and extending to their northwest along the rift valley of the Gulf of Fonseca are fertile lowland plains, with soil highly enriched by ash from nearby volcanoes of the central highlands. Nicaragua's abundance of biologically significant and unique ecosystems contribute to Mesoamerica's designation as a biodiversity hotspot.
The Spanish Empire conquered the region in the 16th century. Nicaragua achieved its independence from Spain in 1821. Since its independence, Nicaragua has undergone periods of political unrest, dictatorship, and fiscal crisis—the most notable causes that led to the Nicaraguan Revolution of the 1960s and 1970s. Prior to the revolution, Nicaragua was one of Central America's wealthiest and most developed countries. The revolutionary conflict, paired with a 1972 earthquake, reversed the country's prior economic standing. Nicaragua is a representative democratic republic, and has experienced economic growth and political stability in recent years. In 1990, Nicaragua elected Violeta Chamorro as its president, making it the first country in Central American history and the second in the Western Hemisphere to democratically elect a female head of state.
The population of Nicaragua, approximately 6 million, is multiethnic. Roughly a quarter of the population lives in the capital city, Managua; it is the second-largest city in Central America. Segments of the population include indigenous native tribes from the Mosquito Coast, Europeans, Africans, Asians, and people of Middle Eastern origin. The main language is Spanish, although native tribes on the eastern coast speak their native languages, such as Miskito, Sumo, and Rama, as well as English Creole. The mixture of cultural traditions has generated substantial diversity in art and literature, particularly the latter given the various literary contributions of Nicaraguan writers, including Rubén Darío, Ernesto Cardenal, and Gioconda Belli. The biological diversity, warm tropical climate, and active volcanoes make Nicaragua an increasingly popular tourist destination.
El Salvador (Spanish: República de El Salvador, literally 'Republic of The Savior') is the smallest and the most densely populated country in Central America. The country's capital city and largest city is San Salvador; Santa Ana and San Miguel are also important cultural and commercial centers in the country as well as Central America. El Salvador borders the Pacific Ocean on the west, and the countries of Guatemala to the north and Honduras to the east. Its easternmost region lies on the coast of the Gulf of Fonseca, opposite Nicaragua. As of 2009, El Salvador had a population of approximately 5,744,113 people, composed predominantly of Mestizos.
The colón was the official currency of El Salvador from 1892 to 2001, when it adopted the U.S. Dollar.
In 2010 El Salvador ranked in the top 10 among Latin American countries in terms of the Human Development Index and in the top 3 in Central America (behind Costa Rica and Panama), due in part to ongoing rapid industrialization. In addition, tropical forests and overall forest cover has expanded by nearly 20 percent from the year 1992 to 2010, making it one of the few countries experiencing reforestation.
Spring in Vasanello
Lazio is full of beautiful places. Here is a quick look at Vasanello: Etruscan tombs, old mill on the river, pieces of terra cotta from a Roman kiln, the castle in Vasanello. It was a great sunny day in early April and we were on an excursion with the group called Tesori del Lazio...
CACCIA AL CINGHIALE TIRO INCREDIBILE CON TRIPLETTA DI CINGHIALI in una frazione di secondo
Lugari’s Hunting Videos è il Canale della Caccia made in Italy . Centinaia di videoclip di caccia realistica prodotte in 25 anni di attività sul campo e raccolte in un unico canale tematico , suddiviso in diverse e specifiche Categorie quali : la Caccia al Cinghiale in Battuta, , La Caccia alla Beccaccia col cane da ferma , Caccia a Fagiani , starne , pernici ecc.ra con il cane da ferma e da cerca , La Caccia alla Lepre con i segugi , Caccia di Selezione agli Ungulati e altre tipologie di Caccia da Appostamento ad Oche, Anatre, Colombacci , Tortore , Turdidi , Limicoli e piccola migratoria.
Lugari's Hunting Videos is the channel of hunting made in Italy. Hundreds of video clips of realistic hunting produced in 25 years of field activities and collected in a single topic channel, divided into several specific categories such as: Wild Boar Hunting, Woodcock hunting with pointing dog, Pheasants Hunt , gray partridges, the Hare Hunting with hounds, Selection Hunting of deers, buck, roe deer and Chamoix and other types of standing Hunting to Geese, Ducks, Pigeons, doves, Thrushes, Waders and other small migratory birds.
Vidéos de chasse de Lugari est le canal de chasse fait en Italie. Des centaines de clips vidéo de chasse réaliste produits en 25 ans d'activités sur le terrain et rassemblés dans un seul canal thématique, divisés en plusieurs catégories spécifiques: chasse au sanglier, chasse à la bécasse avec chien de pointage, chasse au faisan, perdrix grise, chasse au lièvre Chasse aux oies, canards, pigeons, colombes, grives, limicoles et autres petits oiseaux migrateurs.
Videos de caza de Lugari es el canal de caza hecho en Italia. Cientos de videoclips de caza realista producidos en 25 años de actividades de campo y recolectados en un solo canal temático, divididos en varias categorías específicas, tales como: caza de jabalíes, caza de gallineros con perro punzante, caza de faisanes, perdices grises, caza de liebres Caza de ciervos, ciervos, ciervos y Chamoix y otros tipos de caza de pie a los gansos, patos, palomas, palomas, zorzales, limícolas y otras pequeñas aves migratorias.