Rottofreno is a comune in the Province of Piacenza in the Italian region Emilia-Romagna, located about 160 kilometres northwest of Bologna and about 12 kilometres west of Piacenza. Rottofreno borders the following municipalities: Borgonovo Val Tidone, Calendasco, Chignolo Po, Gragnano Trebbiense, Monticelli Pavese, Piacenza, and Sarmato. The main settlement of the comune is San Nicolò, which has more inhabitants than Rottofreno proper.
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